Current Issue : October - December Volume : 2020 Issue Number : 4 Articles : 5 Articles
Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major\nconcerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug\ntherapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug\ndelivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing\nthem to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with\na small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We\ndeveloped the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created\nthe target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated\nbio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind\nto the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released\nfrom our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas.\nThus, this hybrid system represents a first step toward an adjuvant therapy that might improve the\nlong-term outcome of endovascular aneurysm repair....
The aim of the present study was to develop and evaluate ethosomal gel containing neomycin sulphate to increase the drug permeation through the skin. The prepared ethosomal gels were also characterized for measurement of pH, spreadability, viscosity, drug content. The ethosomal gels were also evaluated for in-vitro drug release through cellophane membrane and the final best formulation was evaluated for ex-vivo permeation study through pig skin. Amongst all formulations, F6 formulation showed acceptable spreadibility, viscosity and pH value, with maximum entrapment efficiency (81.2%) with excipient concentration i.e. 2% phospholipid and 30% ethanol. The ideal vesicle size was achieved as 4069 nm, with zeta potential 1.36 mV with the PDI of 0.316. In-vitro permeation study showed a release of 89.98 g/cm2 in 8h and ex-vivo permeation studies showed a release of 80.11 g/cm2....
Skin is an attractive site for drug administration partly because of its easy accessibility\nand favorable properties (e.g., less invasiveness and high patient compliance) over some other\ncommon routes of administration. Despite this, the effciency in transdermal drug delivery has been\nlargely limited by poor skin permeation. To address this problem, this study reports the generation\nof oleic acid-containing vesicles, which can enhance the drug delivery eciency while showing\ngood stability and limited skin disruption. Upon being loaded into a complex gel, along with the\nincorporation of the polymer blending technique, a delivery system exhibiting tunable transdermal\nflux of 2,3,5,40-tetrahydroxystilbene 2-O--B-D-glucoside is reported. Taking the good biocompatibility\nand tunable delivery performance into account, our system warrants further development and\noptimization for future applications in the treatment of skin diseases....
Sesamin (SSM) is a water-insoluble compound that is easily eliminated by liver metabolism.\nTo improve the solubility and bioavailability of SSM, this study developed and characterized a\nself-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of SSM and conducted\npharmacokinetic assessments. Oil and surfactant materials suitable for SNEDDS preparation were\nselected on the basis of their saturation solubility at 37 0.5C. The mixing ratios of excipients were\ndetermined on the basis of their dispersibility, transmittance (%), droplet sizes, and polydispersity\nindex. An SNEDDS (F10) formulation comprising glyceryl trioctanoate, polyoxyethylene castor oil,\nand Tween 20 at a ratio of 10:10:80 (w/w/w) was the optimal formulation. This formulation maintained\nover 90% of its contents in different storage environments for 12 weeks. After the self-emulsification\nof SNEDDS, the SSM dispersed droplet size was 66.4 31.4 nm, intestinal permeability increased\nby more than three-fold, relative bioavailability increased by approximately 12.9-fold, and absolute\nbioavailability increased from 0.3% to 4.4%. Accordingly, the developed SNEDDS formulation can\npreserve SSMâ??s solubility, permeability, and bioavailability. Therefore, this SNEDDS formulation\nhas great potential for the oral administration of SSM, which can enhance its pharmacological\napplication value....
Recently, nanogels have been identified as innovative formulations for enlarging the\napplication of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are\nHGs-based aggregates with sizes in the range of nanometers and formulated in order to\nobtain injectable preparations. Regardless of the advantages oered by peptides in a hydrogel\npreparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed.\nHere, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three dierent\nmethods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The eect of the\nhydrophilicâ??lipophilic balance (HLB) in the formulation was also evaluated in terms of size and\nstability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as\nthe model drug, with a drug loading comparable with those of the liposomes....
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